… -based anti-inflammatory compound used for the treatment of … focus mainly on its inhibitory
effects on antioxidant defensive … to the identification of a variety of targets for AUR, and this …

… peroxidase, glutathione-S-transferase, … the inhibition of TrxR, a computational investigation
at DFT level analyzed the ligand exchange reactions of auranofin with the potential target …

… of AMPK can inhibit the mammalian target of rapamycin (… In contrast, microsomal glutathione
S-transferase 1 (MGST1) … There have been various studies demonstrating that auranofin …

… The overall conclusion from our results is that TRi-1 and TRi-2 are more specific TXNRD1
inhibitors than AF, and we identify additional targets of the three drugs that should be …

… of the Trx system inhibitors as targeted therapies for CRC. … PL has been identified as an
inhibitor for glutathione-s-transferase … Auranofin is a gold (I)-containing compound that has been …

… gold compounds [9], it was demonstrated that AUF targets … is an efficient TrxR inhibitor,
whereas such an inhibition of TrxR … synthetase (GSS) and glutathione S-transferase Mu 3 (GSTM3…

… as glutaredoxin, glutathione S-transferase and protein disulfide … Auranofin can inhibit
cytosolic and mitochondrial TrxR via … cells, phosphine gold (I) containing compounds of AF with …

… of this gold(I) compound are mainly due to direct inhibition of … target of AF, we applied this
exposure condition to improve the understanding of the importance of its enzymatic inhibition …

… Auranofin was the first inorganic gold complex to be described as a powerful inhibitor of …
others (cathepsin B; glutathione S-transferase, kinases) that is targeted by metal complexes. …

… This study suggested that bacterial TrxR is the primary target of auranofin. Inhibition of
TrxR … and affects the corresponding protein functions, such as glutathione-S-transferase [120], …